DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women | Zendy

Paula DominguezSalas | Zendy; Sophie E. Moore | Zendy; Darren Cole | Zendy; Kerry-Ann da Costa | Zendy; Sharon E. Cox | Zendy; Roger Dyer | Zendy; Anthony J. C. Fulford | Zendy; Sheila M. Innis | Zendy; Robert A. Waterland | Zendy; Steven H. Zeisel | Zendy; Andrew M. Prentice | Zendy; Branwen J. Hennig | Zendy

Open Access

DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women

Author(s) -

Paula DominguezSalas,

Sophie E. Moore,

Darren Cole,

Kerry-Ann da Costa,

Sharon E. Cox,

Roger Dyer,

Anthony J. C. Fulford,

Sheila M. Innis,

Robert A. Waterland,

Steven H. Zeisel,

Andrew M. Prentice,

Branwen J. Hennig

Publication year - 2013

Publication title -

american journal of clinical nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.608

H-Index - 336

eISSN - 1938-3207

pISSN - 0002-9165

DOI - 10.3945/ajcn.112.048462

Subject(s) - riboflavin , betaine , choline , offspring , b vitamins , methionine , homocysteine , vitamin , biology , endocrinology , medicine , physiology , biochemistry , pregnancy , genetics , amino acid

Animal models show that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated by epigenetic changes in DNA. In humans, altered DNA methylation patterns have been observed in offspring whose mothers were exposed to famine or who conceived in the Gambian rainy season.

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