Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease
Author(s) -
Joyce B. J. van Meurs,
Guillaume Paré,
Stephen M. Schwartz,
Aditi Hazra,
Toshiko Tanaka,
Sita H. Vermeulen,
Ioana Cotlarciuc,
Xin Yuan,
Anders Mälarstig,
Stefania Bandinelli,
Joshua C. Bis,
Henk J. Blom,
Matthew A. Brown,
Constance Chen,
Yii-Der Chen,
Robert Clarke,
Abbas Dehghan,
Jeanette Erdmann,
Luigi Ferrucci,
Anders Hamsten,
Albert Hofman,
David J. Hunter,
Anuj Goel,
Andrew D. Johnson,
Sekar Kathiresan,
Ellen Kampman,
Douglas P. Kiel,
Lambertus A. Kiemeney,
John C. Chambers,
Peter Kraft,
Jan Lindemans,
Barbara McKnight,
Christopher P. Nelson,
Christopher J. O’Donnell,
Bruce M. Psaty,
Paul M. Ridker,
Fernando Rivadeneira,
Lynda M. Rose,
Udo Seedorf,
David S. Siscovick,
Heribert Schunkert,
Jacob Selhub,
Per Magne Ueland,
Péter Vollenweider,
Gérard Waeber,
Dawn Waterworth,
Hugh Watkins,
Jacqueline C.M. Witteman,
Martin den Heijer,
Paul F. Jacques,
André G. Uitterlinden,
Jaspal S. Kooner,
Dan Rader,
Muredach P. Reilly,
Vincent Mooser,
Daniel I. Chasman,
Nilesh J. Samani,
Kourosh R. Ahmadi
Publication year - 2013
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.3945/ajcn.112.044545
Subject(s) - methylenetetrahydrofolate reductase , genome wide association study , coronary artery disease , medicine , single nucleotide polymorphism , homocysteine , genetic association , genetics , genotype , biology , allele , genetic variation , gene
The strong observational association between total homocysteine (tHcy) concentrations and risk of coronary artery disease (CAD) and the null associations in the homocysteine-lowering trials have prompted the need to identify genetic variants associated with homocysteine concentrations and risk of CAD.
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