Dietary polyamine intake and risk of colorectal adenomatous polyps
Author(s) -
Ashley J. Vargas,
Betsy C. Wertheim,
Eugene W. Gerner,
Cynthia A. Thomson,
Cheryl L. Rock,
Patricia A. Thompson
Publication year - 2012
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.3945/ajcn.111.030353
Subject(s) - colorectal adenoma , adenoma , medicine , spermidine , polyamine , gastroenterology , spermine , colorectal cancer , ornithine decarboxylase , putrescine , colonoscopy , endocrinology , familial adenomatous polyposis , biology , cancer , biochemistry , enzyme
Putrescine, spermidine, and spermine are the polyamines required for human cell growth. The inhibition of ornithine decarboxylase (ODC), which is the rate-limiting enzyme of polyamine biosynthesis, decreases tumor growth and the development of colorectal adenomas. A database was developed to estimate dietary polyamine exposure and relate exposure to health outcomes.
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