Open AccessA high-fat meal promotes lipid-load and apolipoprotein B-48 receptor transcriptional activity in circulating monocytes
Author(s) -
Lourdes M. Varela,
Almudena OrtegaGómez,
Beatriz Bermúdez,
Sergio López,
Yolanda M. Pacheco,
José R. Villar,
Rocı́o Abia,
Francisco J.G. Muriana
Publication year - 2011
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.3945/ajcn.110.007765
Subject(s) - postprandial , endocrinology , medicine , apolipoprotein b , cholesterol , lipid metabolism , triglyceride , monocyte , biology , chemistry , insulin
The postprandial metabolism of dietary fats results in the production of apolipoprotein B-48 (apoB48)-containing triglyceride-rich lipoproteins (TRLs), which cause rapid receptor-mediated macrophage lipid engorgement via the apoB48 cell surface receptor (apoB48R). Monocytes circulate together with apoB48-containing TRLs in the postprandial bloodstream and may start accumulating lipids even before their migration to tissues and differentiation to macrophages.
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