Open AccessGenetic variants in the FADS gene cluster are associated with arachidonic acid concentrations of human breast milk at 1.5 and 6 mo postpartum and influence the course of milk dodecanoic, tetracosenoic, and trans-9-octadecenoic acid concentrations over the duration of lactation
Author(s) -
Eva Lattka,
Peter Rzehak,
Éva Szabó,
Viktória Jakobik,
Melanie N. Weck,
Maria Weyermann,
Harald Grallert,
Dietrich Rothenbacher,
Joachim Heinrich,
Hermann Brenner,
Támas Décsi,
Thomas Illig,
Berthold Koletzko
Publication year - 2010
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.3945/ajcn.110.004515
Subject(s) - arachidonic acid , breastfeeding , breast milk , polyunsaturated fatty acid , single nucleotide polymorphism , genotype , lactation , linoleic acid , fatty acid , breast feeding , docosahexaenoic acid , biology , endocrinology , medicine , genetics , pregnancy , gene , biochemistry , pediatrics , enzyme
Breastfeeding is considered an optimal nutritional source of n-6 (omega-6) and n-3 (omega-3) fatty acids (FAs) for the proper visual and cognitive development of newborn children. In addition to maternal nutrition as an important regulator of FA concentrations, first results exist on an association of breast-milk FAs with single nucleotide polymorphisms (SNPs) in the FADS gene cluster, which encodes the rate-limiting enzymes in the elongation-desaturation pathway of long-chain polyunsaturated fatty acids (LC-PUFAs).
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