IMPACT OF OXYDATIVE STRESS ON EARLY POSTOPERATIVE KNEE FUNCTIONS AND MUSCLE INJURY BIOCHEMICAL MARKERS. CAN WE CREATE AN ISCHAEMIC PRECONDITIONING EFFECT IN SEQUENTIAL ISCHAEMIC SURGICAL PROCEDURES? | Zendy

Erdem Aktaş | Zendy; Çiğdem Atay | Zendy; Mehmet Deveci | Zendy; Murat Arıkan | Zendy; Güray Toğral | Zendy; Ahmet Yıldırım | Zendy

Open Access

IMPACT OF OXYDATIVE STRESS ON EARLY POSTOPERATIVE KNEE FUNCTIONS AND MUSCLE INJURY BIOCHEMICAL MARKERS. CAN WE CREATE AN ISCHAEMIC PRECONDITIONING EFFECT IN SEQUENTIAL ISCHAEMIC SURGICAL PROCEDURES?

Author(s) -

Erdem Aktaş,

Çiğdem Atay,

Mehmet Deveci,

Murat Arıkan,

Güray Toğral,

Ahmet Yıldırım

Publication year - 2015

Publication title -

acta orthopaedica et traumatologica turcica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.586

H-Index - 28

eISSN - 2589-1294

pISSN - 1017-995X

DOI - 10.3944/aott.2015.14.0352

Subject(s) - medicine , tourniquet , lactate dehydrogenase , creatine kinase , anesthesia , ischemia , womac , malondialdehyde , reperfusion injury , total knee arthroplasty , surgery , oxidative stress , osteoarthritis , pathology , biochemistry , chemistry , alternative medicine , enzyme

Simultaneous bilateral total knee arthroplasty (TKA) with prolonged tourniquet time has the potential to trigger ischemia-reperfusion injury, which can adversely affect knee function. Studies suggest that the magnitude of injury is less if it occurs following an ischemic event which takes place in another part of the body, known as ischemic preconditioning (IPC). The purpose of this study was to investigate the impact of oxidative stress on muscle injury and knee function and to elucidate if potential IPC effect can attenuate ischemia-reperfusion injury metabolites and prevent poor functional outcomes in single-stage bilateral TKA.

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