A new small-animal model for the study of acquired heterotopic ossification after hip surgery | Zendy

Joris Anthonissen | Zendy; Christian Ossendorf | Zendy; Johanna Lisa Hock | Zendy; Ulrike Ritz | Zendy; Alexander Hofmann | Zendy; Pol Maria Rommens | Zendy

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A new small-animal model for the study of acquired heterotopic ossification after hip surgery

Author(s) -

Joris Anthonissen,

Christian Ossendorf,

Johanna Lisa Hock,

Ulrike Ritz,

Alexander Hofmann,

Pol Maria Rommens

Publication year - 2015

Publication title -

acta orthopaedica et traumatologica turcica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.586

H-Index - 28

eISSN - 2589-1294

pISSN - 1017-995X

DOI - 10.3944/aott.2015.14.0271

Subject(s) - medicine , heterotopic ossification , ankylosis , femoral canal , pelvis , surgery , heterotopic bone , animal model , hip surgery , ossification , lesion , animal study , total hip arthroplasty , arthroplasty , endocrinology

Heterotopic ossification (HO)--the formation of bone in soft tissues--is a frequent problem after surgery of the hip and pelvis, but little is known about its underlying pathogenic mechanisms. It is vital to study the underlying pathogenesis in animal models to develop and evaluate new prophylactic regimens directed against HO. However, previously developed small-animal models for the study of HO imitate neither surgery nor trauma-mechanisms that potentially cause HO. Hence, the goal of this study was to develop a novel small-animal model imitating hip surgery that can reliably produce HO.

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