A mathematical model for within-host Toxoplasma gondii invasion dynamics | Zendy

Adam Sullivan | Zendy; Folashade B. Agusto | Zendy; Sharon Bewick | Zendy; Chunlei Su | Zendy; Suzanne Lenhart | Zendy; Xiaopeng Zhao | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A mathematical model for within-host <em>Toxoplasma gondii</em> invasion dynamics

Author(s) -

Adam Sullivan,

Folashade B. Agusto,

Sharon Bewick,

Chunlei Su,

Suzanne Lenhart,

Xiaopeng Zhao

Publication year - 2012

Publication title -

mathematical biosciences and engineering

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.451

H-Index - 45

eISSN - 1551-0018

pISSN - 1547-1063

DOI - 10.3934/mbe.2012.9.647

Subject(s) - toxoplasma gondii , biology , population , host (biology) , parasite hosting , steady state (chemistry) , dynamics (music) , range (aeronautics) , physics , immunology , ecology , antibody , computer science , chemistry , world wide web , acoustics , demography , materials science , sociology , composite material

Toxoplasma gondii (T. gondii) is a protozoan parasite that infects a wide range of intermediate hosts, including all mammals and birds. Up to 20% of the human population in the US and 30% in the world are chronically infected. This paper presents a mathematical model to describe intra-host dynamics of T. gondii infection. The model considers the invasion process, egress kinetics, interconversion between fast-replicating tachyzoite stage and slowly replicating bradyzoite stage, as well as the host's immune response. Analytical and numerical studies of the model can help to understand the influences of various parameters to the transient and steady-state dynamics of the disease infection.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research