Investigation of the relationship between immune checkpoints and mismatch repair deficiency in recurrent and nonrecurrent glioblastoma | Zendy

Emel Çakır | Zendy; İsmail Sayğın | Zendy; Mustafa Emre Erçin | Zendy

Open Access

Investigation of the relationship between immune checkpoints and mismatch repair deficiency in recurrent and nonrecurrent glioblastoma

Author(s) -

Emel Çakır,

İsmail Sayğın,

Mustafa Emre Erçin

Publication year - 2021

Publication title -

turkish journal of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.277

H-Index - 27

eISSN - 1303-6165

pISSN - 1300-0144

DOI - 10.3906/sag-2010-166

Subject(s) - microsatellite instability , medicine , pms2 , immunotherapy , immunohistochemistry , immune system , glioblastoma , immune checkpoint , oncology , dna mismatch repair , pd l1 , cancer research , immunology , microsatellite , gene , cancer , biology , genetics , allele , colorectal cancer

Microsatellite instability tests and programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) in the immune checkpoint pathway are the tests that determine who will benefit from immune checkpoint inhibitor therapy. We aimed to show the expression of DNA mismatch repair proteins and PD-1/PD-L1 molecules that inhibit immune checkpoints, to explain the relationship between them, and to demonstrate their predictive role in recurrent and nonrecurrent glioblastoma.

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