The role of anakinra in the modulation of intestinal cell apoptosis and inflammatory response during ischemia/reperfusion | Zendy

Muhammed Kandemir | Zendy; Necdet Fatih Yaşar | Zendy; Mete Özkurt | Zendy; Rumeysa Özyurt | Zendy; Ezgi Bektur | Zendy; Nilüfer Erkasap | Zendy

Open Access

The role of anakinra in the modulation of intestinal cell apoptosis and inflammatory response during ischemia/reperfusion

Author(s) -

Muhammed Kandemir,

Necdet Fatih Yaşar,

Mete Özkurt,

Rumeysa Özyurt,

Ezgi Bektur,

Nilüfer Erkasap

Publication year - 2021

Publication title -

turkish journal of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.277

H-Index - 27

eISSN - 1303-6165

pISSN - 1300-0144

DOI - 10.3906/sag-2008-258

Subject(s) - anakinra , medicine , malondialdehyde , tunel assay , superoxide dismutase , reperfusion injury , ischemia , apoptosis , catalase , interleukin 1 receptor antagonist , interleukin , pharmacology , inflammation , tumor necrosis factor alpha , intestinal mucosa , receptor antagonist , immunology , endocrinology , cytokine , antagonist , receptor , oxidative stress , immunohistochemistry , biochemistry , biology , disease

Even though interleukin-1 receptor antagonist, IL-1Ra, is used in certain inflammatory diseases, its effect on ischemia-reperfusion injury is a current research topic. We aimed to investigate the protective effects of anakinra, an IL-1Ra, on the I/R induced intestinal injury.

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