Protective and therapeutic effect of hydrogen sulfide on hemorrhagic cystitis and testis dysfunction induced with cyclophosphamide | Zendy

Fikriye Yasemin Ozatık | Zendy; Orhan Özatik | Zendy; Yasemin Tekşen | Zendy; Semra Yiğitaslan | Zendy; Neziha Senem Arı | Zendy

Open Access

Protective and therapeutic effect of hydrogen sulfide on hemorrhagic cystitis and testis dysfunction induced with cyclophosphamide

Author(s) -

Fikriye Yasemin Ozatık,

Orhan Özatik,

Yasemin Tekşen,

Semra Yiğitaslan,

Neziha Senem Arı

Publication year - 2021

Publication title -

turkish journal of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.277

H-Index - 27

eISSN - 1303-6165

pISSN - 1300-0144

DOI - 10.3906/sag-2003-10

Subject(s) - hemorrhagic cystitis , sodium hydrosulfide , medicine , cyclophosphamide , testosterone (patch) , endocrinology , andrology , immunohistochemistry , pharmacology , hydrogen sulfide , chemotherapy , chemistry , sulfur , organic chemistry

Cyclophosphamide (CP) is a drug used for treatment of many malignant diseases. However, it can cause serious side effects such as hemorrhagic cystitis and male infertility. Hydrogen sulfide (H2S) is a gaseous mediator and is suggested to have antioxidant, antiinflammatory, and antiapoptotic effects. In this study, dose-dependent effects of H2S donor sodium hydrosulfide (NaHS) on cyclophosphamide-induced hemorrhagic cystitis and testicular dysfunction were investigated in rats.

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