Protective effects of apocynin on damaged testes of rats exposed to methotrexate | Zendy

Kübra Kavram Sarıhan | Zendy; Melda Yardımoglu Yılmaz | Zendy; Fatma Ceyla Eraldemir | Zendy; Yusufhan Yazır | Zendy; Esra Acar | Zendy

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Protective effects of apocynin on damaged testes of rats exposed to methotrexate

Author(s) -

Kübra Kavram Sarıhan,

Melda Yardımoglu Yılmaz,

Fatma Ceyla Eraldemir,

Yusufhan Yazır,

Esra Acar

Publication year - 2020

Publication title -

turkish journal of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.277

H-Index - 27

eISSN - 1303-6165

pISSN - 1300-0144

DOI - 10.3906/sag-1909-52

Subject(s) - medicine , methotrexate , malondialdehyde , myeloperoxidase , apocynin , pharmacology , dimethyl sulfoxide , glutathione , saline , white blood cell , adverse effect , antioxidant , endocrinology , oxidative stress , biochemistry , nadph oxidase , enzyme , inflammation , chemistry , organic chemistry

Methotrexate (MTX), widely used as a drug in cancer, has many adverse effects on tissues. Apocynin (APO) is a NADPH oxidase inhibitor and is known with many antioxidant properties. In this study, we aimed to evaluate the adverse effects of MTX on testicular tissue and the protective effects of APO at two different doses (20 mg/kg and 50 mg/kg) on MTX-induced testicular damage.

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