Open AccessOctreotide ameliorates dermal fibrosis in bleomycin-induced scleroderma
Author(s) -
Sibel Oyucu Orhan,
Ahmet Tektemur,
Nevzat Gözel,
İbrahim Özercan,
Servet Yolbaş,
Ahmet Yıldırım,
Ebru Önalan Etem,
Süleyman Serdar Koca
Publication year - 2018
Publication title -
turkish journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 27
eISSN - 1303-6165
pISSN - 1300-0144
DOI - 10.3906/sag-1707-88
Subject(s) - octreotide , medicine , bleomycin , fibrosis , scleroderma (fungus) , therapeutic effect , subcutaneous injection , pulmonary fibrosis , systemic scleroderma , endocrinology , gastroenterology , somatostatin , pathology , chemotherapy , inoculation , dermatomyositis
Insulin-like growth factor (IGF)-I is a differentiation and growth factor. Antifibrotic action of octreotide has been reported in pulmonary fibrosis. The present study aimed to research the prophylactic and therapeutic potential of octreotide on a bleomycin (BLM)-induced experimental scleroderma model.
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