Chemokine CXCR-4 and cyclooxygenase-2 in the pathogenesis of pterygium | Zendy

Gönen Başer | Zendy; Oya Nermin Sivrikoz | Zendy; Eyyüp Karahan | Zendy; Emine Şeker Ün | Zendy; Hakan Yıldırım | Zendy; Sülen Sarıoğlu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Chemokine CXCR-4 and cyclooxygenase-2 in the pathogenesis of pterygium

Author(s) -

Gönen Başer,

Oya Nermin Sivrikoz,

Eyyüp Karahan,

Emine Şeker Ün,

Hakan Yıldırım,

Sülen Sarıoğlu

Publication year - 2017

Publication title -

turkish journal of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.277

H-Index - 27

eISSN - 1303-6165

pISSN - 1300-0144

DOI - 10.3906/sag-1508-91

Subject(s) - stroma , pterygium , medicine , pathogenesis , staining , immunohistochemistry , pathology , epithelium , conjunctiva , chemokine , inflammation , immunology , ophthalmology

Background/aim: This study aimed to investigate the expression of chemokine receptor 4 (CXCR-4) and cyclooxygenase-2 (COX-2) in the epithelium and stroma of pterygium tissue in comparison with healthy conjunctiva. Materials and methods: The expression of CXCR4 and COX-2 was investigated by immunohistochemistry in the epithelium and stroma of the pterygium tissue of 29 eyes and compared with healthy conjunctival tissues. The correlation between CXCR4 and COX-2 expression as well as the correlation of these markers with the area of pterygium were evaluated statistically. Results: COX-2 staining scores were 1.75 ± 0.63 in the epithelium and 1.20 ± 0.62 in the stroma of the pterygium tissue. Mean CXCR-4 staining in the epithelium was 0.069 ± 0.37, whereas it was 5.0 ± 2.84 cells in the stroma. There was almost no staining of COX-2 and CXCR4 in the control samples. There was a strong positive correlation between the expression of CXCR-4 and COX-2 in the stroma of the pterygium. Conclusion: CXCR-4 and COX-2 may play important roles in the pathogenesis of pterygium.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research