Effect of methylprednisolone injection on interleukin-4 and interferon-gamma expression following hepatitis B vaccination in mice | Zendy

Peter Ughachukwu | Zendy; Paul Okonkwo | Zendy; Prince Chiazor Unekwe | Zendy; John Ogama | Zendy

Open Access

Effect of methylprednisolone injection on interleukin-4 and interferon-gamma expression following hepatitis B vaccination in mice

Author(s) -

Peter Ughachukwu,

Paul Okonkwo,

Prince Chiazor Unekwe,

John Ogama

Publication year - 2016

Publication title -

turkish journal of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.277

H-Index - 27

eISSN - 1303-6165

pISSN - 1300-0144

DOI - 10.3906/sag-1504-33

Subject(s) - medicine , methylprednisolone , booster dose , interferon , immunology , immunosuppression , vaccination , cirrhosis , dose , immune system , intramuscular injection , titer , hepatitis b , immunization , virus

The prevalence of hepatitis B infection is high worldwide with liver cirrhosis and hepatocellular carcinoma as important complications. Immunosuppression, especially from corticosteroids, is often cited as a cause of poor immune response and there is documented evidence of irrational administration of glucocorticoids to children and adults. Decreased expression of interleukin-4 and interferon-gamma is an indication of poor humoral and cellular immune responses, respectively. Therefore, we decided to find out if methylprednisolone injection decreases interleukin-4 and interferon-gamma expression following hepatitis B vaccination in mice.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research