Open AccessGenetic association of the COL1A1 gene promoter –1997 G/T (rs1107946) andSp1 +1245 G/T (rs1800012) polymorphisms and keloid scars in a Jeddah population
Author(s) -
Sahah A Linjawi,
Sanaa Tork,
Raysa M Shaibah
Publication year - 2016
Publication title -
turkish journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 27
eISSN - 1303-6165
pISSN - 1300-0144
DOI - 10.3906/sag-1412-41
Subject(s) - single nucleotide polymorphism , haplotype , medicine , scars , genotype , linkage disequilibrium , allele , genetics , gene , biology , pathology
Scars develop at the end of the natural wound-healing process and are characterized by excessive collagen deposition, particularly types I and III collagen. This study aimed to investigate the genetic association of COL1A1 -1997 G/T (rs1107946) and COL1A1 Sp1 +1245 G/T (rs1800012) polymorphisms with the incidence of scars.
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