Open AccessThe effect of vitamin E and L-carnitine against methotrexate-induced injury in rat testis
Author(s) -
Mehmet Yüncü,
Nezahat BÜKÜCÜ,
Nuray Bayat,
Leman Sencar,
Mehmet Tarakçıoğlu
Publication year - 2015
Publication title -
turkish journal of medical sciences
Language(s) - English
Resource type - Journals
eISSN - 1303-6165
pISSN - 1300-0144
DOI - 10.3906/sag-1409-39
Subject(s) - methotrexate , malondialdehyde , medicine , carnitine , superoxide dismutase , antimetabolite , vitamin , saline , endocrinology , vitamin e , andrology , antioxidant , biochemistry , oxidative stress , chemistry
Methotrexate (MTX), used commonly as an antimetabolite drug in cancer therapy, leads to acute toxic side effects in tissues or organs containing rapidly dividing cells, such as bone marrow, gastrointestinal mucosa, and seminiferous tubules. In this study, we investigated the protective effects of vitamin E and L-carnitine against MTX-induced injury in rat testis.
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