Quantitative study of epigenetic signature in head >and necksquamous cell carcinoma | Zendy

Ayesha Umair | Zendy; Bassel Tarakji | Zendy; Alzoghaibi Ibrahim | Zendy; Azzeghaibi NASSER | Zendy; Alenzi Fq | Zendy; Ayesha SHREEN | Zendy

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Quantitative study of epigenetic signature in head >and necksquamous cell carcinoma

Author(s) -

Ayesha Umair,

Bassel Tarakji,

Alzoghaibi Ibrahim,

Azzeghaibi NASSER,

Alenzi Fq,

Ayesha SHREEN

Publication year - 2015

Publication title -

turkish journal of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.277

H-Index - 27

eISSN - 1303-6165

pISSN - 1300-0144

DOI - 10.3906/sag-1402-5

Subject(s) - dna methylation , epigenetics , cancer research , head and neck squamous cell carcinoma , methylation , foxm1 , medicine , cancer , gene expression , biology , downregulation and upregulation , gene , pathology , microbiology and biotechnology , head and neck cancer , genetics

The aberrant upregulation of Forkhead box protein M1 (FOXM1) plays a fundamental role in cancer initiation by perturbing stem cell differentiation. This study aims to investigate the role of FOXMI in epigenetic modification and gene expression of target genes in primary human oral keratinocytes, squamous cell carcinoma cell lines, and head and neck squamous cell carcinoma (HNSCC) tissue biopsies.

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