Tetrahydropyridine: a promising heterocycle for pharmacologically active molecules | Zendy

Noor ul Amin Mohsin | Zendy; Matloob Ahmad | Zendy

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Tetrahydropyridine: a promising heterocycle for pharmacologically active molecules

Author(s) -

Noor ul Amin Mohsin,

Matloob Ahmad

Publication year - 2018

Publication title -

turkish journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.239

H-Index - 46

eISSN - 1303-6130

pISSN - 1300-0527

DOI - 10.3906/kim-1709-4

Subject(s) - pharmacophore , chemistry , combinatorial chemistry , ring (chemistry) , stereochemistry , organic chemistry

The tetrahydropyridine (THP) ring system has received considerable focus due to its excellent ability to act as a pharmacophore. It is recognized as a major constituent in natural alkaloids. THP derivatives have been reported for a diverse range of biological activities. Recent synthetic works contain syntheses of monosubstituted, disubstituted, trisubstituted, highly functionalized, and condensed structures. In this review, we summarize the recent literature dealing with the bioactive nature of this important heterocycle.

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