Synthesis of methyl (E)-2',4''-thiazachalcones and their N-alkyl derivatives, photochemistry with theoretical calculations and antimicrobial activities | Zendy

Asu Usta | Zendy; Ahmet Yaşar | Zendy; Nuran Yaylı | Zendy; Şengül Alpay Karaoğlu | Zendy; NURETTİN YAYLI | Zendy

Open Access

Synthesis of methyl (E)-2',4''-thiazachalcones and their N-alkyl derivatives, photochemistry with theoretical calculations and antimicrobial activities

Author(s) -

Asu Usta,

Ahmet Yaşar,

Nuran Yaylı,

Şengül Alpay Karaoğlu,

NURETTİN YAYLI

Publication year - 2009

Publication title -

turkish journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.239

H-Index - 46

eISSN - 1303-6130

pISSN - 1300-0527

DOI - 10.3906/kim-0809-44

Subject(s) - chemistry , antimicrobial , enterococcus faecalis , alkyl , dimer , staphylococcus aureus , pseudomonas aeruginosa , stereochemistry , stereoselectivity , organic chemistry , combinatorial chemistry , medicinal chemistry , bacteria , catalysis , escherichia coli , biochemistry , genetics , biology , gene

A series of 9 new (E)-thiazachalcones (1-3), and their N -alkyl substituted derivatives (4-6), and stereoselective dimerization products (7-9) were synthesized, then tested for antimicrobial activity against all test microorganisms except Pseudomonas aeruginosa. The new compounds (1-6) without dimerization products (7-9) showed good antimicrobial property against Staphylococcus aureus, Listeria monocitogenes, and Enterococcus faecalis. The possible dimerization products of compounds (1-3) were calculated theoretically. Experimental and theoretical calculation showed that δ -truxinic type dimer is the most stable isomer.

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