Resveratrol inhibits the growth of tumor cells under chronic stress via the ADRB‑2‑HIF‑1α axis | Zendy

Jiguang Ma | Zendy; Mengwen Xue | Zendy; Simei Zhang | Zendy; Liang Cheng | Zendy; Weikun Qian | Zendy; Wanxing Duan | Zendy; Xin Shen | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Resveratrol inhibits the growth of tumor cells under chronic stress via the ADRB‑2‑HIF‑1α axis

Author(s) -

Jiguang Ma,

Mengwen Xue,

Simei Zhang,

Liang Cheng,

Weikun Qian,

Wanxing Duan,

Xin Shen

Publication year - 2018

Publication title -

oncology reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.094

H-Index - 96

eISSN - 1791-2431

pISSN - 1021-335X

DOI - 10.3892/or.2018.6894

Subject(s) - resveratrol , chronic stress , oncogene , apoptosis , molecular medicine , cell cycle , cancer research , cell growth , cell , cancer cell , cancer , biology , pharmacology , chemistry , medicine , endocrinology , biochemistry

Resveratrol is a type of polyphenol that is abundantly present in knotweed and grapes, and has been confirmed to have tumor‑inhibitory properties. However, the effect of resveratrol on tumor cells under chronic stress conditions remains unclear. The aim of the present study was to demonstrate that resveratrol exerts a significant inhibitory effect on the growth and proliferation of tumor cells under chronic stress in a dose‑dependent manner. Furthermore, resveratrol was able to induce apoptosis of cancer cells under chronic stress conditions. Moreover, resveratrol was found to inhibit tumor cells under chronic stress by decreasing the expression of the β2‑adrenergic receptor (ADRB‑2); in addition, the protein expression of hypoxia‑inducible factor (HIF)‑1α was suppressed by resveratrol in a dose‑dependent manner. Thus, these data suggest that resveratrol inhibits the growth of cancer cells under chronic stress by regulating the ADRB‑2‑HIF‑1α axis. In summary, the present study may provide a new basis supporting the use of resveratrol for the prevention and treatment of pancreatic cancer.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research