MicroRNAs in renal cell carcinoma: A systematic review of clinical implications (Review) | Zendy

Ming Li | Zendy; Ying Wang | Zendy; Yongsheng Song | Zendy; Renge Bu | Zendy; Bo Yin | Zendy; Xiang Fei | Zendy; Qizhen Guo | Zendy; Bin Wu | Zendy

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MicroRNAs in renal cell carcinoma: A systematic review of clinical implications (Review)

Author(s) -

Ming Li,

Ying Wang,

Yongsheng Song,

Renge Bu,

Bo Yin,

Xiang Fei,

Qizhen Guo,

Bin Wu

Publication year - 2015

Publication title -

oncology reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.094

H-Index - 96

eISSN - 1791-2431

pISSN - 1021-335X

DOI - 10.3892/or.2015.3799

Subject(s) - renal cell carcinoma , molecular medicine , microrna , oncogene , cancer , bioinformatics , cell cycle , targeted therapy , kidney cancer , identification (biology) , biology , medicine , oncology , gene , biochemistry , botany

Despite recent advances in the understanding of the biology of renal cell carcinoma (RCC), successful surgical treatment and implementation of novel‑targeted therapies, the prognosis for RCC patients remains poor. Late presentation, tumor heterogeneity and in particular the lack of molecular biomarkers for early detection, classification and the surveillance of RCC treatments are major obstacles. The increasing knowledge regarding the functional role of microRNAs (miRNAs) in pathophysiological processes may provide an important link to the identification of suitable therapeutic targets and diagnostic/prognostic biomarkers for RCC. The aim of this review was to provide new insight into the function of miRNAs in the pathogenesis of RCC and to emphasize their potential as diagnostic and prognostic markers, as well as therapeutic targets.

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