MicroRNA-182 inhibits proliferation through targeting oncogenic ANUBL1 in gastric cancer | Zendy

Lin Tang | Zendy; Feng Chen | Zendy; Er-Jun Pang | Zendy; Zhiqi Zhang | Zendy; Bingwei Jin | Zendy; Weifeng Dong | Zendy

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MicroRNA-182 inhibits proliferation through targeting oncogenic ANUBL1 in gastric cancer

Author(s) -

Lin Tang,

Feng Chen,

Er-Jun Pang,

Zhiqi Zhang,

Bingwei Jin,

Weifeng Dong

Publication year - 2015

Publication title -

oncology reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.094

H-Index - 96

eISSN - 1791-2431

pISSN - 1021-335X

DOI - 10.3892/or.2015.3798

Subject(s) - oncogene , cancer , microrna , cancer research , cell cycle , downregulation and upregulation , molecular medicine , biology , cell growth , cancer cell , mechanism (biology) , gene , genetics , philosophy , epistemology

MicroRNA-182 (miR-182) is significantly downregulated in human gastric tissue samples. Overexpression of miR-182 suppresses the proliferation and colony formation of gastric cancer cells. However, new aspects of the mechanism are still emerging in gastric cancer. ANUBL1, also known as ZFAND4 (zinc finger, AN1-type domain 4), its roles are scarely reported in cancer. In this study, we not only showed that ANUBL1 as an oncogene was upregulated and could promote proliferation of SGC-7901 cells, but also demonstrated that its over-expression led to a strong decrease of miR-182 expression and expression of ANUBL1 was in turn directly downregulated by miR-182, thereby establishing a negative feedback loop between miR-182 and ANUBL1. The elucidation of the mechanisms of miR-182 targeting ANUBL1 in gastric cancer helps us to further understand the mechanism of gastric cancer initiation and progression.

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