Sleeping Beauty transposon system harboring HRAS, c-Myc and shp53 induces sarcomatoid carcinomas in mouse skin | Zendy

Sun-Young Jung | Zendy; Simon Weonsang Ro | Zendy; Geunyoung Jung | Zendy; HyeLim Ju | Zendy; Eunsil Yu | Zendy; WooChan Son | Zendy

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Sleeping Beauty transposon system harboring HRAS, c-Myc and shp53 induces sarcomatoid carcinomas in mouse skin

Author(s) -

Sun-Young Jung,

Simon Weonsang Ro,

Geunyoung Jung,

HyeLim Ju,

Eunsil Yu,

WooChan Son

Publication year - 2013

Publication title -

oncology reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.094

H-Index - 96

eISSN - 1791-2431

pISSN - 1021-335X

DOI - 10.3892/or.2013.2264

Subject(s) - hras , sleeping beauty transposon system , biology , carcinogenesis , oncogene , immunohistochemistry , insertional mutagenesis , sarcomatoid carcinoma , pathology , phenotype , molecular medicine , cancer research , transposable element , cancer , cell cycle , medicine , gene , immunology , genetics , colorectal cancer , genome , kras

The Sleeping Beauty transposon system is used as a tool for insertionalmutagenesis and oncogenesis. However, little is known about the exact histologicalphenotype of the tumors induced. Thus, we used immunohistochemical markers toenable histological identification of the type of tumor induced by subcutaneousinjection of the HRAS, c-Myc and shp53 oncogenes in female C57BL/6 mice. The tumorwas removed when it reached 100 mm3 in volume. Subsequently, we used 13 immunohistochemicalmarkers to histologically identify the tumor type. The results suggested thatthe morphology of the tumor was similar to that of sarcomatoid carcinoma.

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