Open AccessmiRNAs in breast cancer tumorigenesis (Review)
Author(s) -
ZHONG JU ZHANG,
Liang Shi
Publication year - 2011
Publication title -
oncology reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.094
H-Index - 96
eISSN - 1791-2431
pISSN - 1021-335X
DOI - 10.3892/or.2011.1611
Subject(s) - microrna , carcinogenesis , biology , breast cancer , oncogene , cancer , computational biology , mechanism (biology) , bioinformatics , cell cycle , cancer research , genetics , gene , philosophy , epistemology
miRNAs are small, endogenous, non-coding RNAs that negatively regulate protein-codingmRNAs at the post-transcriptional level. It is estimated that in humans thousandsof miRNAs are expressed and more than 700 miRNAs have been described to date.About 50% of annotated human miRNAs are detected in regions of fragile sites,which are associated with cancer. The available evidence has shown that miRNAswidely participate in the development or progression of many types of cancers,including breast cancer. The role of miRNAs in breast cancer has been widely investigated;here, we will focus on what is known about the working mechanism of miRNAs indifferent stages of breast cancer development.
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