Association between B‑Myb proto‑oncogene and the development of malignant tumors (Review) | Zendy

Yuelei Jin | Zendy; Gangqiao Qi | Zendy; Guang Chen | Zendy; Chen Wang | Zendy; Xiaoyan Fan | Zendy

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Association between B‑Myb proto‑oncogene and the development of malignant tumors (Review)

Author(s) -

Yuelei Jin,

Gangqiao Qi,

Guang Chen,

Chen Wang,

Xiaoyan Fan

Publication year - 2021

Publication title -

oncology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2021.12427

Subject(s) - oncogene , myb , cell cycle , carcinogenesis , cancer research , biology , e2f , cancer , transcription factor , microrna , molecular medicine , gene , genetics

B-Myb is a critical transcription factor in regulating cell cycle. Dysregulated expression of B-Myb promotes tumor formation and development. B-Myb is a proto-oncogene ubiquitously expressed in proliferating cells, which maintains normal cell cycle progression. It participates in cell apoptosis, tumorigenesis and aging. In addition, B-Myb is overexpressed in several malignant tumors, including breast cancer, lung cancer and hepatocellular carcinoma, and is associated with tumor development. B-Myb expression is also associated with the prognosis of patients with malignant tumors. Both microRNAs and E2F family of transcription factors (E2Fs) contribute to the function of B-Myb. The present review highlights the association between B-Myb and malignant tumors, and offers a theoretical reference for the diagnosis and treatment of malignant tumors.

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