Comparison of the expression levels of lysine‑specific demethylase 1 and survival outcomes between triple‑negative and non‑triple‑negative breast cancer | Zendy

Kangrong Zhao | Zendy; Yanlin Li | Zendy; Tiantian Han | Zendy; Aiqin Sun | Zendy; Wenxuan Bian | Zendy; Mingyue Li | Zendy; Qiong Lin | Zendy; Genbao Shao | Zendy

Open Access

Comparison of the expression levels of lysine‑specific demethylase 1 and survival outcomes between triple‑negative and non‑triple‑negative breast cancer

Author(s) -

Kangrong Zhao,

Yanlin Li,

Tiantian Han,

Aiqin Sun,

Wenxuan Bian,

Mingyue Li,

Qiong Lin,

Genbao Shao

Publication year - 2020

Publication title -

oncology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2020.12363

Subject(s) - triple negative breast cancer , demethylase , carcinogenesis , oncogene , cancer , breast cancer , cancer research , molecular medicine , biology , histone , oncology , medicine , cell cycle , gene , genetics

Lysine-specific demethylase 1 (LSD1) is a nuclear protein and the first histone demethylase to be identified. LSD1 is an evolutionarily conserved member of the FAD-dependent amine oxidase family and serves an important role in controlling gene expression. LSD1 has been implicated in the tumorigenesis and progression of several types of human cancer; however, to the best of our knowledge, the expression levels and clinical significance of LSD1 in triple-negative breast cancer (TNBC) and non-triple-negative breast cancer (NTNBC) have not been investigated in detail. Therefore, the present study aimed to compare the expression levels of LSD1 in TNBC and NTNBC to determine the prognostic significance of LSD1 in breast cancer. Previous studies have suggested that LSD1 may be involved in the carcinogenesis and progression of breast cancer; however, the findings of the present study indicated that LSD1 may not be a suitable molecular treatment target and auxiliary diagnostic indicator for TNBC and NTNBC.

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