ER&alpha; increases endometrial cancer cell resistance to cisplatin via upregulation of BAG3 | Zendy

Shuetsu Abe | Zendy; Masahiro Iwasaki | Zendy; Shutaro Habata | Zendy; Tasuku Mariya | Zendy; Masato Tamate | Zendy; Motoki Matsuura | Zendy; Seiro Satohisa | Zendy; Tsuyoshi Saito | Zendy

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ERα increases endometrial cancer cell resistance to cisplatin via upregulation of BAG3

Author(s) -

Shuetsu Abe,

Masahiro Iwasaki,

Shutaro Habata,

Tasuku Mariya,

Masato Tamate,

Motoki Matsuura,

Seiro Satohisa,

Tsuyoshi Saito

Publication year - 2020

Publication title -

oncology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2020.12281

Subject(s) - cancer research , endometrial cancer , downregulation and upregulation , bag3 , oncogene , viability assay , cancer , estrogen receptor , cancer cell , cell , cell cycle , cell culture , biology , autophagy , medicine , apoptosis , breast cancer , gene , biochemistry , genetics

Endometrial cancer is a leading cause of cancer-associated mortality in women and has a poor prognosis in advanced stages. Our previous study revealed that BCL-2-associated athanogene 3 (BAG3) may contribute to enhancing cell viability through downregulation of microRNA (miR)-29b in endometrial cancer cell lines. In addition, a relationship between estrogen receptor α (ERα) and BAG3 was recently reported in several cancer cell types. The present study investigated the relationship between ERα and BAG3 in endometrial cancer cell lines. The results demonstrated that exogenous ERα overexpression enhanced BAG3 expression in the EMTOKA endometrial cancer cell line, which does not endogenously express ERα, but had no effect on BAG3 expression levels in the Ishikawa cell line, which does endogenously express ERα. In addition, ERα overexpression suppressed miR-29b expression and enhanced the expression of Mcl-1, a mediator situated downstream of BAG3, in EMTOKA cells, but not Ishikawa cells. ERα overexpression also enhanced EMTOKA, but not Ishikawa, endometrial cancer cell viability in the presence of cisplatin. These findings suggested that ERα may contribute to enhancing endometrial cancer cell resistance to anticancer agents through BAG3 overexpression.

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