Cell‑free DNA as a liquid biopsy for early detection of gastric cancer (Review) | Zendy

Zhengbin Huang | Zendy; Haitao Zhang | Zendy; Benjamin Yu | Zendy; Dehua Yu | Zendy

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Cell‑free DNA as a liquid biopsy for early detection of gastric cancer (Review)

Author(s) -

Zhengbin Huang,

Haitao Zhang,

Benjamin Yu,

Dehua Yu

Publication year - 2020

Publication title -

oncology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2020.12264

Subject(s) - liquid biopsy , cancer , cell free fetal dna , molecular medicine , disease , proteomics , population , oncogene , medicine , cell cycle , biopsy , genomics , computational biology , bioinformatics , biology , pathology , gene , genome , genetics , pregnancy , fetus , environmental health , prenatal diagnosis

Gastric cancer (GC) is one of the most common malignant tumors with poor prognosis worldwide, mainly due to the lack of suitable modalities for population-based screening and early detection of this disease. Therefore, novel and less invasive tests with improved clinical utility are urgently required. The remarkable advances in genomics and proteomics, along with emerging new technologies for highly sensitive detection of genetic alterations, have shown the potential to map the genomic makeup of a tumor in liquid biopsies, in order to assist with early detection and clinical management. The present review summarize the current status in the identification and development of cell-free DNA (cfDNA)-based biomarkers in GC, and also discusses their potential utility and the technical challenges in developing practical cfDNA-based liquid biopsy for early detection of GC.

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