Comprehensive bioinformatics analysis of lncRNAs in gastric cancer | Zendy

Dongdong Qi | Zendy; Qiang Wang | Zendy; Meiqing Wu | Zendy; Xiong Zhang | Zendy

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Comprehensive bioinformatics analysis of lncRNAs in gastric cancer

Author(s) -

Dongdong Qi,

Qiang Wang,

Meiqing Wu,

Xiong Zhang

Publication year - 2018

Publication title -

oncology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2018.9707

Subject(s) - molecular medicine , cancer , oncogene , cell cycle , computational biology , cancer research , biology , bioinformatics , medicine

Long non-coding RNAs (lncRNAs) have been generally considered to serve important roles in various types of cancer, including gastric cancer. However, a comprehensive understanding of lncRNAs in gastric cancer requires further study. The present study performed an in-depth study revealed 50 differently expressed lncRNAs. The changed cellular pathways and biological process in gastric cancer were determined. To further confirm the functions of the differently expressed lncRNAs, co-expression networks were constructed between the lncRNAs and mRNA; this lead to the identification of 6 modules, which participated in various cellular pathways. In addition, 2 lncRNAs were identified which were associated with clinical outcome. The biological analysis and experimental evidence suggested that LINC00982 inhibited, while LL22NC03-N14H11.1 promoted the proliferation of gastric cancer cells. These lncRNAs may be considered as potential prognostic factor in gastric cancer.

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