Comparative study between ultrasound-guided fine needle aspiration cytology of axillary lymph nodes and sentinel lymph node histopathology in early-stage breast cancer | Zendy

Lívio Portela Cardoso-Coelho | Zendy; Rafael Soares Borges | Zendy; Airlane Pereira Alencar | Zendy; Larysse Maira Cardoso-Campos-Verdes | Zendy; João Paulo da Silva-Sampaio | Zendy; Umbelina Soares Borges | Zendy; Luíz Henrique Gebrim | Zendy; Benedito Borges da Silva | Zendy

Open Access

Comparative study between ultrasound-guided fine needle aspiration cytology of axillary lymph nodes and sentinel lymph node histopathology in early-stage breast cancer

Author(s) -

Lívio Portela Cardoso-Coelho,

Rafael Soares Borges,

Airlane Pereira Alencar,

Larysse Maira Cardoso-Campos-Verdes,

João Paulo da Silva-Sampaio,

Umbelina Soares Borges,

Luíz Henrique Gebrim,

Benedito Borges da Silva

Publication year - 2017

Publication title -

oncology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2017.5817

Subject(s) - sentinel lymph node , medicine , histopathology , breast cancer , lymph node , biopsy , radiology , axillary lymph nodes , lymph , fine needle aspiration , cancer , breast carcinoma , carcinoma , pathology

The replacement of sentinel lymph node biopsy (SNB) by ultrasound-guided fine-needle aspiration (US-guided FNA) cytology of axillary lymph nodes is controversial, despite the simplicity and reduced cost of the latter. In the present study, US-guided FNA was performed in 27 patients with early-stage breast cancer for comparison with SNB. Data were analyzed by calculation of sample proportions. Tumor subtypes included invasive ductal carcinoma (85%), invasive lobular carcinoma (7%), and tubular and metaplastic carcinoma (4%). FNA had a sensitivity of 45%, specificity of 100%, positive predictive value of 100% and a negative predictive value of 73%. Axillary lymph node cytology obtained by US guided-FNA in patients with breast cancer had a specificity similar to that of sentinel lymph node histopathology in the presence of axillary node metastases. However, when lymph node cytology is negative, it does not exclude the existence of metastatic implants, due to its low sensitivity in comparison to sentinel lymph node histopathology.

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