Genetics and epigenetics of melanoma | Zendy

Xiaoying Zhang | Zendy; Pei-Ying Zhang | Zendy

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Genetics and epigenetics of melanoma

Author(s) -

Xiaoying Zhang,

Pei-Ying Zhang

Publication year - 2016

Publication title -

oncology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2016.5093

Subject(s) - melanoma , epigenetics , molecular medicine , biology , cancer , oncogene , disease , skin cancer , cancer research , cell cycle , pathological , cell , human genetics , pathology , medicine , genetics , gene

Cancer affects multiple organs in the body Malignant melanoma involves the invasion of skin and occasionally mucosal membrane or eye choroidal tissues. The incidence of cutaneous malignant melanoma is on the increase worldwide and is a major concern in current research. The increase is associated with UV irradiation-induced genetic aberrations that stimulate skin melanocytes to develop unlimited growth. This eventually leads to cell immortality, which in turn causes metastases. The present review examines the genetics and epigenetics of this pathological state together with recent perspectives of the therapeutic management of disease.

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