Hypermethylation reduces the expression of PNPLA7 in hepatocellular carcinoma | Zendy

Xiaojiao Zhang | Zendy; Jun Zhang | Zendy; Rui Wang | Zendy; Shicheng Guo | Zendy; Huilu Zhang | Zendy; Yanyun Ma | Zendy; Qingmei Liu | Zendy; Haiyan Chu | Zendy; Xianghong Xu | Zendy; Yitong Zhang | Zendy; Dongqin Yang | Zendy; Jiucun Wang | Zendy; Jie Liu | Zendy

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Hypermethylation reduces the expression of PNPLA7 in hepatocellular carcinoma

Author(s) -

Xiaojiao Zhang,

Jun Zhang,

Rui Wang,

Shicheng Guo,

Huilu Zhang,

Yanyun Ma,

Qingmei Liu,

Haiyan Chu,

Xianghong Xu,

Yitong Zhang,

Dongqin Yang,

Jiucun Wang,

Jie Liu

Publication year - 2016

Publication title -

oncology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2016.4660

Subject(s) - dna methylation , oncogene , hepatocellular carcinoma , liver cancer , cancer , methylation , biology , molecular medicine , cancer research , phospholipase a2 , gene silencing , lipid metabolism , cell cycle , cancer cell , gene expression , endocrinology , enzyme , biochemistry , genetics , gene

Liver cancer has a high morbidity and mortality rate, and is one of the most common types of cancer in men. PNPLA7 is a member of the patatin-like phospholipase domain-containing protein family which is involved in triglyceride hydrolysis, energy metabolism and lipid droplet metabolism. The liver is the most important energy metabolism organ; whether PNPLA7 is deregulated in liver cancer has not been previously reported. In the present study, reverse transcription-quantitative polymerase chain reaction and subsequent methylation analysis provided evidence that PNPLA7 is down-regulated in hepatocellular carcinoma (HCC) cell lines and tissue samples, via the mechanism of transcriptional silencing by promoter hypermethylation. These results may provide novel insights for HCC diagnosis.

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