Leptomeningeal metastasis from early glottic laryngeal cancer: A case report | Zendy

Zhenyu Pan | Zendy; Guozi Yang | Zendy; Limei Qu | Zendy; Tingting Yuan | Zendy; Xiaochuan Pang | Zendy; Yongxiang Wang | Zendy; Weiyan Shi | Zendy; Lihua Dong | Zendy

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Leptomeningeal metastasis from early glottic laryngeal cancer: A case report

Author(s) -

Zhenyu Pan,

Guozi Yang,

Limei Qu,

Tingting Yuan,

Xiaochuan Pang,

Yongxiang Wang,

Weiyan Shi,

Lihua Dong

Publication year - 2015

Publication title -

oncology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2015.3643

Subject(s) - medicine , larynx , cancer , radiology , vomiting , radiation therapy , magnetic resonance imaging , brain metastasis , metastasis , head and neck cancer , surgery

The present study reports the case of a 53-year-old man with leptomeningeal metastasis from early glottic laryngeal cancer. The patient had been diagnosed with squamous cell carcinoma of the glottic larynx 9 years previously. The current symptoms included a recurring headache that had persisted for 1 month and vomiting for 1 week. A magnetic resonance imaging scan of the head revealed multiple enhancing lesions in the brain and multiple line-like enhancements in the brain fold. Computed tomography scans of the head, neck, chest and abdomen showed no nodular lesions. Cytological examination of the cerebral spinal fluid (CSF) revealed malignant cells with a scattered distribution pattern. The patient received intra-CSF methotrexate chemotherapy concurrent with whole-brain radiotherapy, which relieved the neurological symptoms. To the best of our knowledge, this is the first case of cytologically-confirmed LM from early glottic laryngeal cancer.

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