Immunohistochemical study of vascular endothelial growth factor-C/vascular endothelial growth factor receptor-3 expression in oral tongue squamous cell carcinoma: Correlation with the induction of lymphangiogenesis | Zendy

Tomofumi Naruse | Zendy; Souichi Yanamoto | Zendy; Shinichi Yamada | Zendy; Hidenori Takahashi | Zendy; Yuki Matsushita | Zendy; Naomi Imayama | Zendy; Hisazumi Ikeda | Zendy; Takeshi Shiraishi | Zendy; Shuichi Fujita | Zendy; Tohru Ikeda | Zendy; Izumi Asahina | Zendy; Masahiro Umeda | Zendy

Open Access

Immunohistochemical study of vascular endothelial growth factor-C/vascular endothelial growth factor receptor-3 expression in oral tongue squamous cell carcinoma: Correlation with the induction of lymphangiogenesis

Author(s) -

Tomofumi Naruse,

Souichi Yanamoto,

Shinichi Yamada,

Hidenori Takahashi,

Yuki Matsushita,

Naomi Imayama,

Hisazumi Ikeda,

Takeshi Shiraishi,

Shuichi Fujita,

Tohru Ikeda,

Izumi Asahina,

Masahiro Umeda

Publication year - 2015

Publication title -

oncology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2015.3565

Subject(s) - lymphangiogenesis , podoplanin , vascular endothelial growth factor c , immunohistochemistry , medicine , vascular endothelial growth factor , pathology , lymph node , lymphatic vessel , cancer research , metastasis , oncology , cancer , vascular endothelial growth factor a , vegf receptors

The aim of the present study was to elucidate the associations between the expression of the vascular endothelial growth factor-C (VEGF-C)/VEGF receptor-3 (VEGFR-3) axis and lymphangiogenesis, regional lymph node metastasis and clinicopathological factors in oral tongue squamous cell carcinoma (OTSCC) using immunohistochemistry. The expression of VEGF-C, VEGFR-3 and podoplanin was immunohistochemically evaluated in specimens obtained from 65 patients with OTSCC (T1-2, N0) who had undergone radical surgery alone. The associations between the expression of VEGF-C, VEGFR-3 and podoplanin, and lymphangiogenesis, regional lymph node metastasis and clinocopathological factors were determined by immunohistochemical analysis. VEGF-C, VEGFR-3 and combined VEGF-C/VEGFR-3 expression was significantly higher in cases with regional recurrence compared with those without lymph node involvement (P<0.001). As regards lymphangiogenesis, a significant correlation was observed between podoplanin expression and VEGF-C, VEGFR-3 and combined VEGF-C/VEGFR-3 expression (P<0.001). Therefore, lymphangiogenesis in the peritumoral stroma was associated with lymph node metastasis. However, podoplanin expression did not exhibit a significant correlation with the progression of lymph node metastasis. The results of the present study suggest that the VEGF-C/VEGFR-3 axis may be associated with lymph node metastasis through lymphangiogenesis. Determining the VEGF-C/VEGFR-3 expression status may help predict which patients will develop regional recurrence and provide novel targets for therapies to suppress lymph node metastasis in the treatment of OTSCC.

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