Open AccessAnalysis of ERCC1 and ERCC2 gene variants in osteosarcoma, colorectal and breast cancer
Author(s) -
Benjamín GómezDíaz,
María de la Luz Ayala-Madrigal,
Melva GutiérrezAngulo,
Aura Erazo Valle-Solís,
Luis Miguel Linares-González,
Roberto González-Guzmán,
DAVID CRUZ-GUILLÉN,
Ana Lilia Cedeño-Garcidueñas,
Patricia Canto,
Luz Berenice López-Hernández
Publication year - 2015
Publication title -
oncology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.766
H-Index - 54
eISSN - 1792-1082
pISSN - 1792-1074
DOI - 10.3892/ol.2015.2894
Subject(s) - ercc2 , ercc1 , genotyping , genotype , single nucleotide polymorphism , breast cancer , colorectal cancer , oncology , cancer , biology , medicine , cancer research , genetics , gene , nucleotide excision repair , dna repair
The Asn118Asn (rs11615) variant in the ERCC1 gene, and the Lys751Gln (rs13181) and Asp312Asn (rs1799793) variants in the ERCC2 gene have been associated with the development of varied types of cancer. The aim of the present study was to test for any association between the ERCC1 and ERCC2 gene variants and three different types of cancer in Mexican-mestizo patients. Patients and their respective controls were formed into three groups: The osteosarcoma group, with 28 patients and 97 controls; the colorectal group, with 108 patients and 119 controls; and the breast cancer group, with 71 patients and 74 controls. Genotyping was performed using TaqMan probes and quantitative polymerase chain reaction. Allele and genotype frequencies were compared using a χ 2 test. Only one SNP (rs1799793) was found to be associated with breast cancer. This is the first study analyzing the SNPs in ERCC1 and ERCC2 genes and the susceptibility to cancer in Mexican-mestizo patients with osteosarcoma, and colorectal and breast cancer.
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