Upregulation of the B7/CD28 family member B7-H3 in bladder cancer | Zendy

Deyao Wu | Zendy; Zichun Zhang | Zendy; HUIXING PAN | Zendy; YUANFENG FAN | Zendy; Ping Qü | Zendy; Jian Zhou | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Upregulation of the B7/CD28 family member B7-H3 in bladder cancer

Author(s) -

Deyao Wu,

Zichun Zhang,

HUIXING PAN,

YUANFENG FAN,

Ping Qü,

Jian Zhou

Publication year - 2014

Publication title -

oncology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2014.2828

Subject(s) - immunohistochemistry , oncogene , bladder cancer , downregulation and upregulation , molecular medicine , cancer , biology , cell cycle , messenger rna , pathology , real time polymerase chain reaction , nat , cancer research , medicine , gene , genetics , computer network , computer science

Dysregulation of B7-H3 has been observed in a variety of types of human cancers. In the present study, the mRNA expression level of B7-H3 was analyzed in bladder cancer by performing semi-quantitative reverse transcription-polymerase chain reaction on clinical specimens from transitional cell carcinomas (TCCs) and their normal adjacent tissues (NATs). Immunohistochemical analysis was performed to compare the protein expression level of B7-H3 in TCCs and the paired NATs. The present study indicated that the B7-H3 mRNA expression level was significantly higher in the TCC samples compared with the paired NAT samples. Furthermore, immunohistochemical analyses indicated that the B7-H3 protein expression level was significantly upregulated in the TCC samples compared with in the paired NAT samples, indicating that B7-H3 dysregulation may be important in the progression of bladder cancer.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research