The expression of Wnt-1 inducible signaling pathway protein-2 in astrocytoma: Correlation between pathological grade and clinical outcome | Zendy

Gelei Xiao | Zendy; Zhi Tang | Zendy; Xianrui Yuan | Zendy; Jian Yuan | Zendy; Jie Zhao | Zendy; Zhiping Zhang | Zendy; Zhengwen He | Zendy; Jingping Liu | Zendy

Open Access

The expression of Wnt-1 inducible signaling pathway protein-2 in astrocytoma: Correlation between pathological grade and clinical outcome

Author(s) -

Gelei Xiao,

Zhi Tang,

Xianrui Yuan,

Jian Yuan,

Jie Zhao,

Zhiping Zhang,

Zhengwen He,

Jingping Liu

Publication year - 2014

Publication title -

oncology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2014.2663

Subject(s) - astrocytoma , wnt signaling pathway , oncogene , carcinogenesis , pathology , immunohistochemistry , pathological , biology , cancer research , molecular medicine , pathogenesis , reverse transcription polymerase chain reaction , cell cycle , signal transduction , medicine , cell , cancer , glioma , gene expression , gene , microbiology and biotechnology , genetics , biochemistry

Wnt-1 inducible signaling pathway protein-2 (WISP-2) is a member of the CCN family, which is critical for the control of cell morphology, motion, adhesion and other processes involved in tumorigenesis. The expression pattern and clinical significance of WISP-2 in astrocytomas remains unclear. In this study, reverse transcription-polymerase chain reaction was performed to systematically investigate the expression of WISP-2 in 47 astrocytoma tissues of different pathological grades and 10 normal brain tissues. The mRNA expression levels of WISP-2 in the astrocytoma tissues were observed to be significantly higher than those in the normal brain tissues. Furthermore, the upregulation of WISP-2 was found to be associated with astrocytomas of higher pathological grades. Subsequently, 154 astrocytoma and 15 normal brain tissues were analyzed using immunohistochemistry and similar results were obtained. Univariate and multivariate survival analyses were used to determine the correlations between WISP-2 expression and overall survival (OS) and progression-free survival (PFS). The results indicated that the expression of WISP-2 was found to negatively correlate with patient PFS and OS. These results demonstrated that the WISP-2 protein is involved in the pathogenesis and progression of human astrocytomas and may serve as a malignant biomarker of this disease.

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