Overexpression of the Survivin gene in SGC7901 cell resistance to cisplatin | Zendy

Hanzhang Dong | Zendy; Gaogao Liu | Zendy; Biao Jiang | Zendy; Jiubing Guo | Zendy; Guoquan Tao | Zendy; WEI YIU | Zendy; Jingsong Zhou | Zendy; Guoxin Li | Zendy

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Overexpression of the Survivin gene in SGC7901 cell resistance to cisplatin

Author(s) -

Hanzhang Dong,

Gaogao Liu,

Biao Jiang,

Jiubing Guo,

Guoquan Tao,

WEI YIU,

Jingsong Zhou,

Guoxin Li

Publication year - 2014

Publication title -

oncology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2014.2463

Subject(s) - survivin , oncogene , cisplatin , cell cycle , molecular medicine , gene , cell , cancer research , biology , genetics , chemotherapy

The aim of the present study was to investigate the mechanism of SGC7901 cell resistance to cisplatin (CDDP). SGC7901/CDDP cells were established by the long-term continuous exposure of SGC7901 cells to CDDP in stepwise concentration increments. The morphologies of the SGC7901/CDDP and SGC7901 cells were observed by microscopy. The expression levels of Survivin mRNA and protein in the SGC7901/CDDP and SGC7901 cells were examined by reverse transcription polymerase chain reaction and western blotting respectively. The results revealed morphological differences between the SGC7901 and SGC7901/CDDP cells. The expression levels of Survivin mRNA and protein were significantly higher in the SGC7901/CDDP cells than in the SGC7901 cells. Therefore, high expression levels of the Survivin gene may explain SGC7901 cell resistance to CDDP.

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