The anti-proliferative effects and mechanisms of low molecular weight scorpion BmK venom peptides on human hepatoma and cervical carcinoma cells in vitro | Zendy

Weiling Li | Zendy; Yi Xin | Zendy; Yang Chen | Zendy; Xinli Li | Zendy; Cuili Zhang | Zendy; Jing Bai | Zendy; Jieli Yuan | Zendy

Open Access

The anti-proliferative effects and mechanisms of low molecular weight scorpion BmK venom peptides on human hepatoma and cervical carcinoma cells in vitro

Author(s) -

Weiling Li,

Yi Xin,

Yang Chen,

Xinli Li,

Cuili Zhang,

Jing Bai,

Jieli Yuan

Publication year - 2014

Publication title -

oncology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2014.2336

Subject(s) - hela , oncogene , apoptosis , venom , molecular medicine , scorpion , in vitro , cell cycle , cancer research , cervical carcinoma , carcinoma , cell growth , biology , cancer , microbiology and biotechnology , chemistry , pharmacology , cervical cancer , medicine , biochemistry , pathology , genetics

Peptides from scorpion venom have been previously studied for use in the prevention and treatment of various types of cancer in folk medicine. The present study investigated the anti-proliferative effects and mechanisms of the low molecular weight (~3 kDa) BmK scorpion venom peptides (LMWSVP) on human hepatoma (SMMC 7721) and cervical carcinoma (HeLa) cells. The data indicated that LMWSVP inhibited the growth of SMMC 7721 cells, but had no effect on the growth of HeLa cells. SMMC 7721 cells were more sensitive, with a higher affinity, to LMWSVP as compared with HeLa cells. In addition, LMWSVP induced apoptosis of SMMC 7721 cells by upregulating the expression of caspase-3 and downregulating the expression of Bcl-2. These data provide an experimental basis for further purification and application of LMWSVP for use as an anti-tumor drug in clinical trials.

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