Open AccessChronic lymphocytic leukemia presenting with ascites diagnosed by clonality analysis via gene rearrangement assay: A case report
Author(s) -
YenMin Huang,
LEE-YUNG SHIH,
Po Dunn,
PoNan Wang,
MingChung Kuo,
JinHou Wu,
TungLiang Lin,
TzungChih Tang,
Hung Chang,
HsiaoWen Kao,
HSUAN-JEN SHIH,
YuShin Hung
Publication year - 2014
Publication title -
oncology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.766
H-Index - 54
eISSN - 1792-1082
pISSN - 1792-1074
DOI - 10.3892/ol.2014.2044
Subject(s) - chronic lymphocytic leukemia , oncogene , gene rearrangement , ascites , molecular medicine , cancer research , cell cycle , leukemia , cancer , gene , biology , medicine , pathology , immunology , genetics
The diagnosis of chronic lymphocytic leukemia (CLL) presenting with ascites is predominantly based on the morphological and immunophenotypic characteristics, which are comparable to peripheral blood and bone marrow cells. However, it is relatively difficult to diagnose CLL due to the pleomorphism of the lymphocytes in ascites. The current study presents an 80-year-old male with a prior diagnosis of CLL who developed large ascites. Predominant T lymphocytes rendered morphological and immunophenotypic diagnosis difficult. Clonality analysis of immunoglobulin (Ig) gene rearrangements was performed on the lymphocytes from the ascites to diagnose the involvement of CLL, a laparotomy and biopsy from the peritoneal node confirmed the involvement of small lymphocytic lymphoma/CLL. The clonality analysis of Ig gene rearrangements may provide a powerful and accurate method for diagnosing CLL presenting with ascites.
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