Metastasis-associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells | Zendy

Haili Zhang | Zendy; Dong Yang | Zendy; Haijuan Wang | Zendy; Shuxin Wen | Zendy; Jian Liu | Zendy; Qing-chun Luan | Zendy; Yixuan Huang | Zendy; Binquan Wang | Zendy; Lin Chen | Zendy; Haili Qian | Zendy

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Metastasis-associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells

Author(s) -

Haili Zhang,

Dong Yang,

Haijuan Wang,

Shuxin Wen,

Jian Liu,

Qing-chun Luan,

Yixuan Huang,

Binquan Wang,

Lin Chen,

Haili Qian

Publication year - 2013

Publication title -

oncology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2013.1729

Subject(s) - oncogene , molecular medicine , cell cycle , cell , metastasis , basal cell , cancer research , cancer , laryngeal neoplasm , biology , medicine , pathology , genetics

Overexpression of the metastasis-associated gene 1 ( MTA1 ) has previously been found to be associated with progression of various cancer types to the metastasis stage. The function of MTA1 in laryngeal squamous cell carcinoma (LSCC) remains unclear. To explore the significance of MTA1 in the invasion and migration processes in LSCC, gene transfection and RNA interference (RNAi) were performed to study the biological function of MTA1 in the LSCC cell line, HEP-2. Results showed that MTA1 promoted the invasion, adhesion and migration behavior of LSCC cells. RNAi against MTA1 significantly decreased the malignant phenotypes of cancer cells. MTA1 may be important in the process of LSCC invasion and metastasis.

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