Severe aplastic anemia preceding acute monocytic leukemia in an adult with acquired trisomy 21: A case report | Zendy

Dongmei Guo | Zendy; Qinqin Liu | Zendy; Banban Li | Zendy; Qingliang Teng | Zendy

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Severe aplastic anemia preceding acute monocytic leukemia in an adult with acquired trisomy 21: A case report

Author(s) -

Dongmei Guo,

Qinqin Liu,

Banban Li,

Qingliang Teng

Publication year - 2013

Publication title -

oncology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2013.1724

Subject(s) - acute monocytic leukemia , medicine , aplastic anemia , trisomy 8 , monocytic leukemia , acute leukemia , induction chemotherapy , chemotherapy , trisomy , anemia , leukemia , immunology , pediatrics , cytogenetics , bone marrow , chromosome , biology , gene , biochemistry , genetics

The current case report presents a patient with acute monocytic leukemia (AML-M5) occurring 14 years following the successful treatment of severe aplastic anemia (SAA) with immunosuppressants and androgens. The patient was treated with induction chemotherapy, but did not achieve remission. The patient succumbed to central nervous system bleeding 2 weeks following the first cycle of chemotherapy. Chromosomal examination revealed 47,XX,+21[10]/46,XX[1]. To the best of our knowledge the present case is the first to be reported of SAA 14 years preceding AML-M5 with acquired trisomy 21.

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