Endoplasmic reticulum stress in diethylnitrosamine-induced rat liver cancer | Zendy

Bin Xiao | Zendy; LI-MIN CUI | Zendy; Dongjie Ma | Zendy; Shuangping Liu | Zendy; Xuewu Zhang | Zendy

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Endoplasmic reticulum stress in diethylnitrosamine-induced rat liver cancer

Author(s) -

Bin Xiao,

LI-MIN CUI,

Dongjie Ma,

Shuangping Liu,

Xuewu Zhang

Publication year - 2013

Publication title -

oncology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2013.1651

Subject(s) - endoplasmic reticulum , molecular medicine , oncogene , cancer , chemistry , microbiology and biotechnology , cell cycle , cell , cancer research , biology , biochemistry , medicine

To analyze the significance of endoplasmic reticulum stress (ERS) in the development of diethylnitrosamine (DEN)-induced liver cancer in rats, critical regulatory factors in ERS signaling pathways were investigated in the present study. The results showed that the expression of ERS-related proteins gradually increased in the early and mid-term stages of carcinogenesis, while in the later stages, the expression of these proteins did not change significantly after reaching a peak. ERS is involved in DEN-induced rat liver injury, the proliferation of liver cells and the occurrence and development of liver cirrhosis. However, ERS did not affect hepatoma cell growth following the formation of rat liver cancer in the current study.

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