miRNA: The nemesis of gastric cancer (Review) | Zendy

Xiaohui Xu | Zendy; Xiaodong Yang | Zendy; Chungen Xing | Zendy; Shuyu Zhang | Zendy; Jianping Cao | Zendy

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miRNA: The nemesis of gastric cancer (Review)

Author(s) -

Xiaohui Xu,

Xiaodong Yang,

Chungen Xing,

Shuyu Zhang,

Jianping Cao

Publication year - 2013

Publication title -

oncology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2013.1428

Subject(s) - oncogene , cancer , microrna , molecular medicine , cell cycle , cancer research , apoptosis , computational biology , biology , medicine , genetics , gene

microRNAs (miRNAs) are a group of small non-coding RNAs that are ~22 (18 to 25) nucleotides (nt) long and have been associated with a variety of diseases, including cancer. Increasing evidence indicates that miRNAs are essential in the development, diagnosis, treatment and prognosis of a variety of tumors. The utility of miRNAs as biomarkers for diagnosis and of target molecules for the treatment of cancers is increasingly being recognized. With the discovery of circulating miRNAs, a non-invasive approach for the diagnosis and treatment of cancer has been identified. This review summarizes the role of miRNAs in the development of different tumors, as well as a variety of other biological events. Moreover, this review focuses on analyzing the function and mechanism of gastric cancer-related miRNAs and investigates the importance of circulating miRNAs in gastric cancer, as well as their origin. Finally, this review lists a number of the problems that must be solved prior to miRNAs being used as reliable non-invasive tools for the diagnosis, treatment and prognosis of gastric cancer.

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