Aberrant expression of ZNF268 alters the growth and migration of ovarian cancer cells | Zendy

Li Hu | Zendy; Wei Wang | Zendy; Jinyang Cai | Zendy; Jun Luo | Zendy; Yi Huang | Zendy; Xiong Shilu | Zendy; Wenxin Li | Zendy; Mingxiong Guo | Zendy

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Aberrant expression of ZNF268 alters the growth and migration of ovarian cancer cells

Author(s) -

Li Hu,

Wei Wang,

Jinyang Cai,

Jun Luo,

Yi Huang,

Xiong Shilu,

Wenxin Li,

Mingxiong Guo

Publication year - 2013

Publication title -

oncology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2013.1318

Subject(s) - carcinogenesis , ovarian cancer , gene knockdown , oncogene , cancer research , cell cycle , biology , immunostaining , cell growth , cancer , cell , blot , ovarian carcinoma , molecular medicine , apoptosis , immunohistochemistry , immunology , gene , genetics

Ovarian cancer is one of the most lethal gynaecological cancers worldwide. However, the mechanisms underlying ovarian carcinogenesis are not well understood. The present study used immunostaining, western blotting and quantitative real-time PCR to demonstrate that ZNF268 is overexpressed in human ovarian carcinomas. ZNF268-knockdown increased the viability, colony formation and growth of in vivo xenografts of ovarian carcinoma SKOV-3 cells, whereas SKOV-3 cell migration was inhibited. Furthermore, it was demonstrated that the knockdown of ZNF268 may increase SKOV-3 cell growth by promoting cell cycle progression. The findings suggest that ZNF268 is a novel protein involved in ovarian carcinogenesis and that it may aid in the understanding of the mechanisms of ovarian carcinogenesis.

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