Biomarkers in endometrial cancer: Possible clinical applications (Review) | Zendy

Kouji Banno | Zendy; Iori Kisu | Zendy; Megumi Yanokura | Zendy; Kosuke Tsuji | Zendy; Kenta Masuda | Zendy; Arisa Ueki | Zendy; Yusuke Kobayashi | Zendy; Wataru Yamagami | Zendy; Hiroyuki Nomura | Zendy; Eiichiro Tominaga | Zendy; Nobuyuki Susumu | Zendy; Daisuke Aoki | Zendy

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Biomarkers in endometrial cancer: Possible clinical applications (Review)

Author(s) -

Kouji Banno,

Iori Kisu,

Megumi Yanokura,

Kosuke Tsuji,

Kenta Masuda,

Arisa Ueki,

Yusuke Kobayashi,

Wataru Yamagami,

Hiroyuki Nomura,

Eiichiro Tominaga,

Nobuyuki Susumu,

Daisuke Aoki

Publication year - 2012

Publication title -

oncology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2012.654

Subject(s) - endometrial cancer , cancer , oncogene , biology , dna microarray , microarray , cell cycle , gene , biomarker , molecular medicine , cancer research , endometrium , bioinformatics , oncology , medicine , gene expression , genetics , endocrinology

The number of cases of endometrial cancer has shown a tendency to increase in recent years. Endometrial cancer originates from the endometrium and is classified, based on the development mechanism, into types 1 and 2, which are responsive and non-responsive to estrogen, respectively, and have significantly different gene expression profiles. Studies of genes with abnormal expression in endometrial cancer have identified multiple oncogenes, tumor suppressors, mismatch repair genes, apoptosis-associated genes, levels of hormone receptors and DNA ploidy and aneuploidy as biomarkers of endometrial cancer. The use of these molecules and genes may facilitate accurate diagnosis and prognostic prediction and contribute to individualized treatment. Trials of drugs which target these biomarkers and searches for new biomarkers using cDNA microarrays and RT-qPCR are ongoing and it is likely that these findings can be translated to clinical use.

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