Open AccessSevoflurane suppresses proliferation by upregulating microRNA-203 in breast cancer cells
Author(s) -
Jiaying Liu,
Longqiu Yang,
Xia Guo,
Guangli Jin,
Qimin Wang,
Dongdong Lv,
JunLi Liu,
Chen Qiu,
Qiong Song,
Baolin Li
Publication year - 2018
Publication title -
molecular medicine reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.727
H-Index - 56
eISSN - 1791-3004
pISSN - 1791-2997
DOI - 10.3892/mmr.2018.8949
Subject(s) - sevoflurane , oncogene , cell growth , breast cancer , cell cycle , cancer research , cancer , cell , microrna , cancer cell , apoptosis , signal transduction , downregulation and upregulation , medicine , biology , microbiology and biotechnology , pharmacology , biochemistry , gene
Rapid proliferation is one of the critical characteristics of breast cancer. However, the underlying regulatory mechanism of breast cancer cell proliferation is largely unclear. The present study indicated that sevoflurane, one of inhalational anesthetics, could significantly suppress breast cancer cell proliferation by arresting cell cycle at G1 phase. Notably, the rescue experiment indicated that miR-203 was upregulated by sevoflurane and mediated the function of sevoflurane on suppressing the breast cancer cell proliferation. The present study indicated the function of the sevoflurane/miR-203 signaling pathway on regulating breast cancer cell proliferation. These results provide mechanistic insight into how the sevoflurane/miR-203 signaling pathway supresses proliferation of breast cancer cells, suggesting the sevoflurane/miR-203 pathway may be a potential target in the treatment of breast cancer.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom