Expression signatures of long non-coding RNAs in early brain injury following experimental subarachnoid hemorrhage | Zendy

Bingjie Zheng | Zendy; Huailei Liu | Zendy; Ruke Wang | Zendy; Shancai Xu | Zendy; Yaohua Liu | Zendy; KaiKai Wang | Zendy; Xu Hou | Zendy; Chen Shen | Zendy; Jianing Wu | Zendy; Xin Chen | Zendy; Pei Wu | Zendy; Guang Zhang | Zendy; Zhiyong Ji | Zendy; Hongyu Wang | Zendy; Yao Xiao | Zendy; Jian-Yi Han | Zendy; Huaizhang Shi | Zendy; Shiguang Zhao | Zendy

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Expression signatures of long non-coding RNAs in early brain injury following experimental subarachnoid hemorrhage

Author(s) -

Bingjie Zheng,

Huailei Liu,

Ruke Wang,

Shancai Xu,

Yaohua Liu,

KaiKai Wang,

Xu Hou,

Chen Shen,

Jianing Wu,

Xin Chen,

Pei Wu,

Guang Zhang,

Zhiyong Ji,

Hongyu Wang,

Yao Xiao,

Jian-Yi Han,

Huaizhang Shi,

Shiguang Zhao

Publication year - 2015

Publication title -

molecular medicine reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.727

H-Index - 56

eISSN - 1791-3004

pISSN - 1791-2997

DOI - 10.3892/mmr.2015.3474

Subject(s) - oncogene , subarachnoid hemorrhage , molecular medicine , cell cycle , apoptosis , biology , coding (social sciences) , long non coding rna , pathology , medicine , neuroscience , gene , rna , genetics , mathematics , statistics

Subarachnoid hemorrhage (SAH) is an important cause of mortality in stroke patients. Long non-coding RNAs (LncRNAs) have important functions in brain disease, however their expression profiles in SAH remain to be elucidated. The present study aimed to investigate the expression signatures of LncRNAs and mRNAs in early brain injury (EBI) following SAH in a rat model. Male Wistar rats were randomly divided into an SAH group and a sham operation group. The expression signatures of the LncRNAs and mRNAs in the temporal lobe cortex were investigated using a rat LncRNAs array following experimental SAH. The results revealed that there were 144 downregulated and 64 upregulated LncRNAs and 181 downregulated and 221 upregulated mRNAs following SAH. Additionally, two upregulated (BC092207, MRuc008hvl) and three downregulated (XR_006756, MRAK038897, MRAK017168) LncRNAs were confirmed using reverse transcription quantitative polymerase chain reaction. The differentially expressed mRNAs were further analyzed using the Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes (KEGG) databases. The pathway analysis results provided by the KEGG database indicated that eight pathways associated with inflammation were involved in EBI following SAH. In conclusion, these results demonstrated that the expression profiles of the LncRNAs and mRNAs were significantly different between the SAH-induced EBI group and the sham operation group. These differently expressed LncRNAs may be important in EBI following SAH.

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