Long non-coding RNAs: Novel links in respiratory diseases (Review) | Zendy

Yanru Liu | Zendy; Ruifeng Zhang | Zendy; Kejing Ying | Zendy

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Long non-coding RNAs: Novel links in respiratory diseases (Review)

Author(s) -

Yanru Liu,

Ruifeng Zhang,

Kejing Ying

Publication year - 2015

Publication title -

molecular medicine reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.727

H-Index - 56

eISSN - 1791-3004

pISSN - 1791-2997

DOI - 10.3892/mmr.2015.3290

Subject(s) - biology , epigenetics , computational biology , oncogene , transcriptome , long non coding rna , bioinformatics , lung cancer , cancer , rna , cell cycle , gene , genetics , gene expression , medicine

Long non‑coding RNAs (lncRNAs) represent a surprisingly novel field in mammalian transcriptome research. With the development of RNA sequencing technology and computational methods, lncRNAs have been demonstrated to have important roles in biological processes at the epigenetic, transcription and post‑transcriptional levels. In addition, the dysregulation of lncRNAs contributes to numerous diseases, including cancer and cardiovascular diseases. The present review discusses the important functions of lncRNAs in respiratory diseases, highlights the mechanistic roles which underlie lncRNAs in lung cancer as well as considers the current and future potential use of lncRNAs as novel biomarkers and therapeutic targets for the treatment of lung cancer.

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